FAS2

In Drosophila, Fasciclin 2 (Fas2) has been intensively studied due to its role in nervous system development and maintenance; yet, Fas2 is most abundantly expressed in the adult renal (Malpighian) tubule rather than in neuronal tissues. Fas2 is essential to brush border maintenance in renal tubules of Drosophila. Fas2 is dynamically expressed during tubule morphogenesis, localizing to the brush border whenever the tissue is transport competent. The protein acts as a neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

Full Name

Fas2

Research Area

Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.

Biological Process

Axonal fasciculation Source: FlyBase
Axon guidance Source: GO_Central
Behavioral response to ethanol Source: FlyBase
Bolwig's organ morphogenesis Source: FlyBase
Cell morphogenesis involved in neuron differentiation Source: FlyBase
Dendrite self-avoidance Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
Imaginal disc-derived male genitalia morphogenesis Source: FlyBase
Learning or memory Source: FlyBase
Motor neuron axon guidance Source: FlyBase
Mushroom body development Source: FlyBase
Negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
Negative regulation of neuron remodeling Source: FlyBase
Neuromuscular junction development Source: FlyBase
Neuron recognition Source: FlyBase
Olfactory learning Source: FlyBase
Photoreceptor cell axon guidance Source: FlyBase
Regulation of synapse structure or activity Source: FlyBase
Regulation of synaptic assembly at neuromuscular junction Source: FlyBase
Regulation of synaptic plasticity Source: FlyBase
Regulation of tube diameter, open tracheal system Source: FlyBase
Regulation of tube length, open tracheal system Source: FlyBase
Short-term memory Source: FlyBase
Synapse organization Source: FlyBase
Terminal button organization Source: FlyBase

Cellular Location

Cell membrane

Topology

Extracellular: 29-751
Helical: 752-769
Cytoplasmic: 770-873