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FBXO7

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]
Full Name
F-Box Protein 7
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.
Biological Process
Autophagy of mitochondrion Source: UniProtKB
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
Negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Negative regulation of hydrogen peroxide-induced neuron death Source: ParkinsonsUK-UCL
Negative regulation of lymphocyte differentiation Source: Ensembl
Negative regulation of oxidative stress-induced neuron death Source: ParkinsonsUK-UCL
Positive regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Protein targeting to mitochondrion Source: UniProtKB
Protein ubiquitination Source: ParkinsonsUK-UCL
Regulation of locomotion Source: ParkinsonsUK-UCL
Regulation of neuron projection development Source: ParkinsonsUK-UCL
Regulation of protein stability Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
Cellular Location
Mitochondrion; Nucleus; Cytoplasm; Cytosol. Predominantly cytoplasmic (PubMed:16096642). A minor proportion is detected in the nucleus (PubMed:16096642). Relocates from the cytosol to depolarized mitochondria (PubMed:23933751).
Involvement in disease
Parkinson disease 15 (PARK15):
A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia.

Anti-FBXO7 antibodies

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Target: FBXO7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D8L4E
Application*: WB
Target: FBXO7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G8
Application*: E, IC, IF, WB
Target: FBXO7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0418
Application*: E, WB
Target: FBXO7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0419
Application*: WB
Target: FBXO7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0417
Application*: IF, E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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