Rabbit Anti-FBXO7 Recombinant Antibody (CBXF-0419) (V2LY-0925-LY489)

Name: Rabbit Anti-FBXO7 Recombinant Antibody (CBXF-0419)
SKU: V2LY-0925-LY489
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-0419

Application

Immunogen

Recombinant protein specific to the N-terminus of human FBXO7 protein.

Host Species

Rabbit

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HEPES & BSA & Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

F-Box Protein 7

Entrez Gene ID

25793

UniProt ID

Q9Y3I1

Research Area

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.

Biological Process

Autophagy of mitochondrion Source: UniProtKB
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
Negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Negative regulation of hydrogen peroxide-induced neuron death Source: ParkinsonsUK-UCL
Negative regulation of lymphocyte differentiation Source: Ensembl
Negative regulation of oxidative stress-induced neuron death Source: ParkinsonsUK-UCL
Positive regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Protein targeting to mitochondrion Source: UniProtKB
Protein ubiquitination Source: ParkinsonsUK-UCL
Regulation of locomotion Source: ParkinsonsUK-UCL
Regulation of neuron projection development Source: ParkinsonsUK-UCL
Regulation of protein stability Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL

Cellular Location

Mitochondrion; Nucleus; Cytoplasm; Cytosol. Predominantly cytoplasmic (PubMed:16096642). A minor proportion is detected in the nucleus (PubMed:16096642). Relocates from the cytosol to depolarized mitochondria (PubMed:23933751).

Involvement in disease

Parkinson disease 15 (PARK15):
A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia.

Zhong, Y., Li, J., Ye, M., & Jin, X. (2022). The characteristics of FBXO7 and its role in human diseases. Gene, 146972.

Palmer, M. C., Neudorf, N. M., Farrell, A. C., Razi, T., Lichtensztejn, Z., & McManus, K. J. (2022). The F-box protein, FBXO7, is required to maintain chromosome stability in humans. Human molecular genetics, 31(9), 1471-1486.

Harris, R., Yang, M., Schmidt, C., Royet, C., Singh, S., Natarajan, A., ... & Laman, H. (2022). Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells. Journal of Cell Biology, 221(7), e202203095.

Shen, J. Z., Qiu, Z., Wu, Q., Zhang, G., Harris, R., Sun, D., ... & Spruck, C. (2022). A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells. Molecular Cell, 82(6), 1123-1139.

Noda, S., Sato, S., Fukuda, T., Ueno, S., Tada, N., & Hattori, N. (2022). Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice. Molecular Brain, 15(1), 1-5.

Lee, S. H., Jung, S., Lee, Y. J., Hyun, M., & Chung, K. C. (2021). FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity. Journal of Biological Chemistry, 297(6).

Huang, T., Fang, L., He, R., Weng, H., Chen, X., Ye, Q., & Qu, D. (2021). Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels. Aging (Albany NY), 13(1), 77.

Liu, Y., Lear, T. B., Verma, M., Wang, K. Z., Otero, P. A., McKelvey, A. C., ... & Mallampalli, R. K. (2020). Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1. JCI insight, 5(11).

Correa‐Vela, M., Lupo, V., Montpeyó, M., Sancho, P., Marcé‐Grau, A., Hernández‐Vara, J., ... & Espinós, C. (2020). Impaired proteasome activity and neurodegeneration with brain iron accumulation in FBXO7 defect. Annals of clinical and translational neurology, 7(8), 1436-1442.

Joseph, S., Schulz, J. B., & Stegmüller, J. (2018). Mechanistic contributions of FBXO7 to Parkinson disease. Journal of neurochemistry, 144(2), 118-127.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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