GAL3ST4

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq]

Full Name

galactose-3-O-sulfotransferase 4

Function

Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.

Biological Process

Cell-cell signaling Source: UniProtKB
Glycolipid biosynthetic process Source: InterPro
Glycoprotein biosynthetic process Source: MGI
Glycoprotein metabolic process Source: UniProtKB
Oligosaccharide metabolic process Source: UniProtKB
Proteoglycan biosynthetic process Source: UniProtKB
Sulfur compound metabolic process Source: UniProtKB

Cellular Location

Golgi stack membrane

Topology

Cytoplasmic: 1-18
Helical: 19-39
Lumenal: 40-486