GALR2

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

galanin receptor 2

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231).

The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Feeding behavior Source: ProtInc
Galanin-activated signaling pathway Source: GO_Central
Inositol phosphate metabolic process Source: Ensembl
Learning or memory Source: ProtInc
Multicellular organism development Source: ProtInc
Muscle contraction Source: ProtInc
Negative regulation of adenylate cyclase activity Source: InterPro
Neuron projection development Source: Ensembl
Neuropeptide signaling pathway Source: GO_Central
Phosphatidylinositol metabolic process Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Positive regulation of large conductance calcium-activated potassium channel activity Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB

Cell membrane

Extracellular: 1-28
Helical: 29-49
Cytoplasmic: 50-60
Helical: 61-81
Extracellular: 82-99
Helical: 100-121
Cytoplasmic: 122-141
Helical: 142-162
Extracellular: 163-187
Helical: 188-208
Cytoplasmic: 209-237
Helical: 238-258
Extracellular: 259-260
Helical: 261-281
Cytoplasmic: 282-387