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GBP2

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

Full Name

Guanylate Binding Protein 2

Function

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832).

Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).

Biological Process

Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Defense response to Gram-positive bacterium Source: GO_Central
Defense response to protozoan Source: GO_Central
Immune response Source: ProtInc
Protein localization to nucleus Source: UniProtKB

Cellular Location

Cytoplasm; Golgi apparatus membrane; Perinuclear region; Membrane. GBP2-GBP5 dimers localize to the Golgi apparatus.

PTM

Isoprenylation is required for proper subcellular location.

Anti-GBP2 antibodies

Mouse Anti-GBP2 Recombinant Antibody (CBFYH-0269) (CBMAB-H1143-FY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0269

Application*: WB, IH

Mouse Anti-GBP2 Recombinant Antibody (CBFYH-0270) (CBMAB-H1144-FY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-0270

Application*: WB, IH, IF, F

Mouse Anti-GBP2 Recombinant Antibody (CBFYH-0271) (CBMAB-H1145-FY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0271

Application*: WB, IH, IF, F

Mouse Anti-GBP2 Recombinant Antibody (1G1) (CBMAB-G2420-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1G1

Application*: F

Mouse Anti-GBP2 Recombinant Antibody (2A10) (CBMAB-G2421-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2A10

Application*: E, IP, WB

Rabbit Anti-GBP2 Recombinant Antibody (CBLG1-2657) (CBMAB-G2429-LY)

SDS

Target: GBP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-2657

Application*: WB

Mouse Anti-GBP2 Recombinant Antibody (CBLG1-2658) (CBMAB-G2430-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2658

Application*: IH, WB

Mouse Anti-GBP2 Recombinant Antibody (CBLG1-2659) (CBMAB-G2431-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog

Clone: CBLG1-2659

Application*: WB

Mouse Anti-GBP2 Recombinant Antibody (1E5) (CBMAB-G2419-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog

Clone: 1E5

Application*: F

Mouse Anti-GBP2 Recombinant Antibody (2G6) (CBMAB-G2422-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2G6

Application*: IC/IF, IH, P, WB

Mouse Anti-Gbp2 Recombinant Antibody (3B8) (CBMAB-G2423-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3B8

Application*: IF, IH, WB

Mouse Anti-GBP2 Recombinant Antibody (4E5) (CBMAB-G2424-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4E5

Application*: F

Mouse Anti-GBP2 Recombinant Antibody (4E7) (CBMAB-G2425-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4E7

Application*: F

Mouse Anti-GBP2 Recombinant Antibody (4H2) (CBMAB-G2426-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4H2

Application*: F

Mouse Anti-GBP2 Recombinant Antibody (5C8) (CBMAB-G2427-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5C8

Application*: F

Mouse Anti-GBP2 Recombinant Antibody (CBLG1-2661) (CBMAB-G2433-LY)

SDS

Target: GBP2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLG1-2661

Application*: WB

GBP2 Matched Antibody Pair (469) (APMAB-469LY)

SDS

Target: GBP2

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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