GBP2

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
Full Name
Guanylate Binding Protein 2
Function
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832).

Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
Biological Process
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Defense response to Gram-positive bacterium Source: GO_Central
Defense response to protozoan Source: GO_Central
Immune response Source: ProtInc
Protein localization to nucleus Source: UniProtKB
Cellular Location
Cytoplasm; Golgi apparatus membrane; Perinuclear region; Membrane. GBP2-GBP5 dimers localize to the Golgi apparatus.
PTM
Isoprenylation is required for proper subcellular location.
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Anti-GBP2 antibodies

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Mouse Anti-GBP2 Recombinant Antibody (CBLG1-2661) (CBMAB-G2433-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2661
Application*: WB
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (CBLG1-2659) (CBMAB-G2431-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: CBLG1-2659
Application*: WB
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (CBLG1-2658) (CBMAB-G2430-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2658
Application*: IH, WB
Datasheet SDS

Rabbit Anti-GBP2 Recombinant Antibody (CBLG1-2657) (CBMAB-G2429-LY)

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Target: GBP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2657
Application*: WB
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (5C8) (CBMAB-G2427-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C8
Application*: F
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (4H2) (CBMAB-G2426-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4H2
Application*: F
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (4E7) (CBMAB-G2425-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E7
Application*: F
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (4E5) (CBMAB-G2424-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E5
Application*: F
Datasheet SDS

Mouse Anti-Gbp2 Recombinant Antibody (3B8) (CBMAB-G2423-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B8
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (2G6) (CBMAB-G2422-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G6
Application*: IC/IF, IH, P, WB
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (2A10) (CBMAB-G2421-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A10
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (1G1) (CBMAB-G2420-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1G1
Application*: F
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (1E5) (CBMAB-G2419-LY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: 1E5
Application*: F
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (CBFYH-0271) (CBMAB-H1145-FY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0271
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (CBFYH-0270) (CBMAB-H1144-FY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0270
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-GBP2 Recombinant Antibody (CBFYH-0269) (CBMAB-H1143-FY)

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Target: GBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0269
Application*: WB, IH
Datasheet SDS

GBP2 Matched Antibody Pair (469) (APMAB-469LY)

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Target: GBP2
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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