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Mouse Anti-GBP2 Recombinant Antibody (2G6) (CBMAB-G2422-LY)

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Basic Information

Host Animal
Mouse
Clone
2G6
Application
ICC/IF, IHC, IHC-P, WB
Immunogen
Protein expressed in 293T cell transfected with human GBP2 expression vector
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Guanylate Binding Protein 2
Introduction
This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
Entrez Gene ID
2634
UniProt ID
P32456
Alternative Names
Guanylate Binding Protein 2; Guanylate Binding Protein 2; Interferon-Inducible; Interferon-Induced Guanylate-Binding Protein 2; Guanine Nucleotide-Binding Protein 2; GTP-Binding Protein 2; EC 3.6.5.-; HuGBP-2; GBP-2;
Function
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832).

Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
Biological Process
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Defense response to Gram-positive bacterium Source: GO_Central
Defense response to protozoan Source: GO_Central
Immune response Source: ProtInc
Protein localization to nucleus Source: UniProtKB
Cellular Location
Cytoplasm; Golgi apparatus membrane; Perinuclear region; Membrane. GBP2-GBP5 dimers localize to the Golgi apparatus.
PTM
Isoprenylation is required for proper subcellular location.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GBP2 Matched Antibody Pair (469) (CAT#: APMAB-469LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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