GDPD2

This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. This protein may have a role in osteoblast differentiation and growth. Alternate splicing results in multiple transcript variants.

Full Name

glycerophosphodiester phosphodiesterase domain containing 2

Function

Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity).

Biological Process

Actin filament reorganization Source: Ensembl
Lipid metabolic process Source: InterPro
Positive regulation of osteoblast differentiation Source: Ensembl

Cellular Location

Cytoskeleton; Cytoplasm; Cell membrane. Colocalizes with the actin cytoskeleton.

Topology

Cytoplasmic: 1-38
Helical: 39-59
Extracellular: 60-85
Helical: 86-106
Cytoplasmic: 107-121
Helical: 122-142
Extracellular: 143-154
Helical: 155-175
Cytoplasmic: 176-188
Helical: 189-209
Extracellular: 210-490
Helical: 491-511
Cytoplasmic: 512-539