GEM

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq]

Full Name

GTP binding protein overexpressed in skeletal muscle

Function

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Chromosome organization Source: UniProtKB
Immune response Source: ProtInc
Metaphase plate congression Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Negative regulation of high voltage-gated calcium channel activity Source: InterPro
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

PTM

Phosphorylated on tyrosine residues.

Anti-GEM antibodies

Mouse Anti-GEM Recombinant Antibody (4B12) (CBMAB-G2791-LY)

Datasheet

SDS

Target: GEM

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4B12

Application*: E, WB

Mouse Anti-GEM Recombinant Antibody (CBLG1-3160) (CBMAB-G2792-LY)

Datasheet

SDS

Target: GEM

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3160

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)