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GEM

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq]

Full Name

GTP binding protein overexpressed in skeletal muscle

Function

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Chromosome organization Source: UniProtKB
Immune response Source: ProtInc
Metaphase plate congression Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Negative regulation of high voltage-gated calcium channel activity Source: InterPro
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

PTM

Phosphorylated on tyrosine residues.

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Anti-GEM antibodies

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Mouse Anti-GEM Recombinant Antibody (CBLG1-3160) (CBMAB-G2792-LY)

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Target: GEM

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3160

Application*: WB

Mouse Anti-GEM Recombinant Antibody (4B12) (CBMAB-G2791-LY)

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Target: GEM

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4B12

Application*: E, WB

Mouse Anti-GEM Recombinant Antibody (CBLG1-3160) (V2LY-1225-LY1045)

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Target: GEM

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-3160

Application*: WB, IP, IF, E

Mouse Anti-GEM Recombinant Antibody (4B12) (V2LY-1225-LY1044)

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Target: GEM

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 4B12

Application*: WB, IP, IF, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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