GEM
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq]
Full Name
GTP binding protein overexpressed in skeletal muscle
Function
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Chromosome organization Source: UniProtKB
Immune response Source: ProtInc
Metaphase plate congression Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Negative regulation of high voltage-gated calcium channel activity Source: InterPro
Signal transduction Source: ProtInc
Chromosome organization Source: UniProtKB
Immune response Source: ProtInc
Metaphase plate congression Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Negative regulation of high voltage-gated calcium channel activity Source: InterPro
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
PTM
Phosphorylated on tyrosine residues.
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Anti-GEM antibodies
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Target: GEM
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3160
Application*: WB
Target: GEM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B12
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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