GFRA1

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]
Full Name
GDNF family receptor alpha 1
Function
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
Biological Process
Cell surface receptor signaling pathway Source: UniProtKB
Nervous system development Source: GO_Central
Cellular Location
Cell membrane; Endosome; Multivesicular body; Trans-Golgi network. Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies.
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Anti-GFRA1 antibodies

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Rabbit Anti-GFRA1 Recombinant Antibody (CBLG1-1046) (CBMAB-G3221-LY)

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Target: GFRA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1046
Application*: E
Datasheet SDS

Rabbit Anti-GFRA1 Recombinant Antibody (CBLG1-1045) (CBMAB-G3220-LY)

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Target: GFRA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBLG1-1045
Application*: E, P
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (CBLG1-1044) (CBMAB-G3219-LY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBLG1-1044
Application*: WB
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (CBLG1-1043) (CBMAB-G3218-LY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-1043
Application*: IF, E, WB
Datasheet SDS

Rabbit Anti-GFRA1 Recombinant Antibody (9) (CBMAB-G3217-LY)

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Target: GFRA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 9
Application*: E
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (4G10) (CBMAB-G3214-LY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4G10
Application*: WB
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (4D8) (CBMAB-G3213-LY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4D8
Application*: E, IF
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (3E4) (CBMAB-G3211-LY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E4
Application*: E, WB
Datasheet SDS

Rabbit Anti-GFRA1 Recombinant Antibody (29) (CBMAB-G3209-LY)

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Target: GFRA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 29
Application*: E
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (81401) (CBMAB-G0413-LY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 81401
Application*: WB
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (3H8) (CBMAB-1566-CN)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3H8
Application*: F, IP
Datasheet SDS

Mouse Anti-GFRA1 (AA 24-440) Recombinant Antibody (CBFYH-0336) (CBMAB-H1205-FY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0336
Application*: WB
Datasheet SDS

Mouse Anti-GFRA1 Recombinant Antibody (CBFYH-0335) (CBMAB-H1204-FY)

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Target: GFRA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0335
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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