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Mouse Anti-GFRA1 Recombinant Antibody (3H8) (CBMAB-1566-CN)

This product is a mouse antibody that recognizes GFRA1 of human. The antibody 3H8 can be used for immunoassay techniques such as: FC, IP.
See all GFRA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H8
Antibody Isotype
IgG2b
Application
FC, IP

Basic Information

Immunogen
Recombinant human GFRα1 extracellular domain (aa. 24-440)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
GDNF family receptor alpha 1
Introduction
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. The protein mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
Entrez Gene ID
2674
UniProt ID
P56159
Alternative Names
GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
Function
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
Biological Process
Cell surface receptor signaling pathway Source: UniProtKB
Nervous system development Source: GO_Central
Cellular Location
Cell membrane; Endosome; Multivesicular body; Trans-Golgi network. Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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