GFRA2

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
Gdnf Family Receptor Alpha 2
Function
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

Isoform 2:
participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Biological Process
Negative regulation of protein autophosphorylation Source: Ensembl
Nervous system development Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Cellular Location
Cell membrane
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Anti-GFRA2 antibodies

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Mouse Anti-GFRA2 Recombinant Antibody (11G34) (CBMAB-G3224-LY)

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Target: GFRA2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 11G34
Application*: WB
Datasheet SDS

Rabbit Anti-GFRA2 Recombinant Antibody (104) (CBMAB-G3223-LY)

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Target: GFRA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 104
Application*: WB
Datasheet SDS

Rabbit Anti-GFRA2 Recombinant Antibody (101) (CBMAB-G3222-LY)

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Target: GFRA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 101
Application*: E, WB
Datasheet SDS

Mouse Anti-GFRA2 Recombinant Antibody (71515) (CBMAB-G0415-LY)

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Target: GFRA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 71515
Application*: F
Datasheet SDS

Rabbit Anti-GFRA2 (AA 1-441) Recombinant Antibody (CBFYH-0337) (CBMAB-H1207-FY)

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Target: GFRA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-0337
Application*: E
Datasheet SDS

Mouse Anti-GFRA2 (AA 22-441) Monoclonal Antibody (CBFYH-2972) (CBMAB-H1206-FY)

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Target: GFRA2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYH-2972
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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