Rabbit Anti-GFRA2 Recombinant Antibody (101) (CBMAB-G3222-LY)

Name: Rabbit Anti-GFRA2 Recombinant Antibody (101)
SKU: CBMAB-G3222-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

101

Application

ELISA, WB

Immunogen

Recombinant Human GFRA2 protein. This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA2

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Gdnf Family Receptor Alpha 2

Introduction

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Entrez Gene ID

2675

UniProt ID

O00451

Alternative Names

GDNF Family Receptor Alpha 2; TGF-Beta-Related Neurotrophic Factor Receptor 2; Neurturin Receptor Alpha; GDNF Receptor Beta; GDNFR-Alpha-2; RET Ligand 2; NRTNR-ALPHA; GDNFR-Beta; NTNR-Alpha; GDNFRB; RETL2;

Function

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

Isoform 2:
participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.

Biological Process

Negative regulation of protein autophosphorylation Source: Ensembl
Nervous system development Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Cellular Location

Cell membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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