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Rabbit Anti-GFRA2 Recombinant Antibody (104) (CBMAB-G3223-LY)

This product is antibody recognizes GFRA2. The antibody 104 immunoassay techniques such as: WB.
See all GFRA2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
104
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant Human GFRA2 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Gdnf Family Receptor Alpha 2
Introduction
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Entrez Gene ID
2675
UniProt ID
O00451
Alternative Names
GDNF Family Receptor Alpha 2; TGF-Beta-Related Neurotrophic Factor Receptor 2; Neurturin Receptor Alpha; GDNF Receptor Beta; GDNFR-Alpha-2; RET Ligand 2; NRTNR-ALPHA; GDNFR-Beta; NTNR-Alpha; GDNFRB; RETL2;
Function
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

Isoform 2:
participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Biological Process
Negative regulation of protein autophosphorylation Source: Ensembl
Nervous system development Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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