GGCT

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Full Name
Gamma-Glutamylcyclotransferase
Function
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
Biological Process
Release of cytochrome c from mitochondria Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome
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Anti-GGCT antibodies

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Mouse Anti-GGCT Recombinant Antibody (CBLG1-1048) (CBMAB-G3250-LY)

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Target: GGCT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1048
Application*: E
Datasheet SDS

Rabbit Anti-GGCT Recombinant Antibody (CBLG1-2746) (CBMAB-G3249-LY)

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Target: GGCT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2746
Application*: WB
Datasheet SDS

Human GGCT ELISA Kit (V2LY-0626-LY4604)

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Target: GGCT
Sensitivity: 0.014 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant GGCT protein, His Tag (V2LY-0526-LY4299)

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Target: GGCT
Expressed Host: E. coli
Sequence: Amino Acid: 1-188
Tag: His Tag
Datasheet SDS

Mouse Anti-GGCT Recombinant Antibody (CBLG1-1048) (V2LY-1225-LY1168)

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Target: GGCT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1048
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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