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GGCT

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Full Name

Gamma-Glutamylcyclotransferase

Function

Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.

Biological Process

Release of cytochrome c from mitochondria Source: UniProtKB

Cellular Location

Cytosol; Extracellular exosome

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Anti-GGCT antibodies

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Mouse Anti-GGCT Recombinant Antibody (CBLG1-1048) (CBMAB-G3250-LY)

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Target: GGCT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1048

Application*: E

Rabbit Anti-GGCT Recombinant Antibody (CBLG1-2746) (CBMAB-G3249-LY)

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Target: GGCT

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-2746

Application*: WB

Human Recombinant GGCT protein, His Tag (V2LY-0526-LY4299)

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Target: GGCT

Expressed Host: E. coli

Sequence: Amino Acid: 1-188

Tag: His Tag

Mouse Anti-GGCT Recombinant Antibody (CBLG1-1048) (V2LY-1225-LY1168)

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Target: GGCT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1048

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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