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GP5

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

Full Name

Glycoprotein V Platelet

Function

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.

Biological Process

Blood coagulation Source: UniProtKB-KW
Cell adhesion Source: ProtInc

Cellular Location

Membrane

Topology

Extracellular: 17-523
Helical: 524-544
Cytoplasmic: 545-560

PTM

The N-terminus is blocked.

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Anti-GP5 antibodies

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Armenian Hamster Anti-GP5 Recombinant Antibody (CBYJL-029) (CBMAB-L0058-YJ)

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Target: GP5

Host: Armenian Hamster

Antibody Isotype: IgG

Specificity: Mouse, Rat

Clone: CBYJL-029

Application*: F, IP

Mouse Anti-GP5 Recombinant Antibody (CBWJC-3739) (CBMAB-C5004WJ)

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Target: GP5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJC-3739

Application*: WB

Armenian Hamster Anti-GP5 Recombinant Antibody (CBFYH-3465) (CBMAB-H4013-FY)

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Target: GP5

Host: Armenian Hamster

Antibody Isotype: IgG

Specificity: Mouse, Rat

Clone: CBFYH-3465

Application*: IH, IF, F, IP

Mouse Anti-GP5 Recombinant Antibody (19) (CBMAB-G0653-LY)

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Target: GP5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 19

Application*: F

Mouse Anti-GP5 Recombinant Antibody (CBFYH-0430) (CBMAB-H1302-FY)

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Target: GP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-0430

Application*: E, IP, IF, WB, P

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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