GP5

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
Full Name
Glycoprotein V Platelet
Function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
Biological Process
Blood coagulation Source: UniProtKB-KW
Cell adhesion Source: ProtInc
Cellular Location
Membrane
Topology
Extracellular: 17-523
Helical: 524-544
Cytoplasmic: 545-560
PTM
The N-terminus is blocked.
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Anti-GP5 antibodies

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Armenian Hamster Anti-GP5 Recombinant Antibody (CBYJL-029) (CBMAB-L0058-YJ)

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Target: GP5
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBYJL-029
Application*: F, IP
Datasheet SDS

Mouse Anti-GP5 Recombinant Antibody (CBWJC-3739) (CBMAB-C5004WJ)

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Target: GP5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-3739
Application*: WB
Datasheet SDS

Armenian Hamster Anti-GP5 Recombinant Antibody (CBFYH-3465) (CBMAB-H4013-FY)

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Target: GP5
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBFYH-3465
Application*: IH, IF, F, IP
Datasheet SDS

Mouse Anti-GP5 Recombinant Antibody (19) (CBMAB-G0653-LY)

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Target: GP5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 19
Application*: F
Datasheet SDS

Mouse Anti-GP5 Recombinant Antibody (CBFYH-0430) (CBMAB-H1302-FY)

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Target: GP5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0430
Application*: E, IP, IF, WB, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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