GP9
GP9 (Glycoprotein IX Platelet) is a Protein Coding gene. Diseases associated with GP9 include Bernard-Soulier Syndrome and Blood Platelet Disease. Among its related pathways are Integrin alphaIIb beta3 signaling and GP1b-IX-V activation signalling. An important paralog of this gene is GP1BB.
Full Name
Glycoprotein IX Platelet
Function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Biological Process
Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Cell adhesion Source: ProtInc
Cellular Location
Membrane
Involvement in disease
Bernard-Soulier syndrome (BSS):
A coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption.
A coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption.
Topology
Extracellular: 17-147
Helical: 148-168
Cytoplasmic: 169-177
Helical: 148-168
Cytoplasmic: 169-177
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Anti-GP9 antibodies
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CompareTarget: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: Z1
Application*: E, F, IH, WB
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: S1
Application*: F
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 39
Application*: E, F
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mink
Clone: 14D38
Application*: F, IP
Target: GP9
Sensitivity: 0.0076 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C3532
Application*: IH, F
Target: GP9
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0746
Application*: F, IF, IH
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: G0659
Application*: WB, IH
Target: GP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: H1303
Application*: E, IP, IF, WB
Target: GP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0431
Application*: E, IP, IF, WB, P
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4409
Application*: WB, IH, F
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3242
Application*: WB, IH, F
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4022
Application*: F
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-C2525
Application*: WB, P
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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