GPR26

This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas.

Full Name

G Protein-Coupled Receptor 26

Function

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-10
Helical: 11-31
Cytoplasmic: 32-47
Helical: 48-68
Extracellular: 69-81
Helical: 82-102
Cytoplasmic: 103-123
Helical: 124-144
Extracellular: 145-168
Helical: 169-189
Cytoplasmic: 190-245
Helical: 246-266
Extracellular: 267-276
Helical: 277-297
Cytoplasmic: 298-337