GPR26

This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas.

Full Name

G Protein-Coupled Receptor 26

Function

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-10
Helical: 11-31
Cytoplasmic: 32-47
Helical: 48-68
Extracellular: 69-81
Helical: 82-102
Cytoplasmic: 103-123
Helical: 124-144
Extracellular: 145-168
Helical: 169-189
Cytoplasmic: 190-245
Helical: 246-266
Extracellular: 267-276
Helical: 277-297
Cytoplasmic: 298-337

Anti-GPR26 antibodies

Mouse Anti-GPR26 Recombinant Antibody (CBFYH-0456) (CBMAB-H1329-FY)

Datasheet

SDS

Target: GPR26

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-0456

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)