Mouse Anti-GPR26 Recombinant Antibody (CBFYH-0456) (CBMAB-H1329-FY)

This product is mouse antibody that recognizes GPR26. The antibody CBFYH-0456 can be used for immunoassay techniques such as: FC.
See all GPR26 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-0456

Antibody Isotype

IgG2b

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

G Protein-Coupled Receptor 26

Introduction

This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas.

Entrez Gene ID

2849

UniProt ID

Q8NDV2

Alternative Names

G Protein-Coupled Receptor 26

Function

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-10
Helical: 11-31
Cytoplasmic: 32-47
Helical: 48-68
Extracellular: 69-81
Helical: 82-102
Cytoplasmic: 103-123
Helical: 124-144
Extracellular: 145-168
Helical: 169-189
Cytoplasmic: 190-245
Helical: 246-266
Extracellular: 267-276
Helical: 277-297
Cytoplasmic: 298-337

References

Roy, N., & Parhar, I. (2022). Habenula orphan G-protein coupled receptors in the pathophysiology of fear and anxiety. Neuroscience & Biobehavioral Reviews, 132, 870-883.

Meng, L., Jiang, Y. P., Zhu, J., & Li, B. (2020). MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties. Neurological research, 42(3), 222-227.

Alexander, S. P., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., ... & Yao, C. (2019). The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors. British journal of pharmacology, 176, S21-S141.

Rinne, M., Tanoli, Z. U. R., Khan, A., & Xhaard, H. (2019). Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes. Scientific Reports, 9(1), 1-16.

Alavi, M. S., Shamsizadeh, A., Azhdari-Zarmehri, H., & Roohbakhsh, A. (2018). Orphan G protein-coupled receptors: The role in CNS disorders. Biomedicine & Pharmacotherapy, 98, 222-232.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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