GPR35

Full Name

G protein-coupled receptor 35

Function

Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

Biological Process

Chemokine-mediated signaling pathway Source: MGI
Cytoskeleton organization Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of neuronal action potential Source: Ensembl
Negative regulation of voltage-gated calcium channel activity Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central

Cellular Location

Cell membrane. Internalized to the cytoplasm after exposure to kynurenic acid.

Topology

Extracellular: 1-24
Helical: 25-45
Cytoplasmic: 46-56
Helical: 57-77
Extracellular: 78-90
Helical: 91-112
Cytoplasmic: 113-135
Helical: 136-156
Extracellular: 157-174
Helical: 175-195
Cytoplasmic: 196-218
Helical: 219-239
Extracellular: 240-258
Helical: 259-279
Cytoplasmic: 280-309