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GPR62

Full Name

G protein-coupled receptor 62

Function

Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538).

Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).

Biological Process

G protein-coupled receptor signaling pathway Source: UniProtKB
Inositol phosphate-mediated signaling Source: UniProtKB
Positive regulation of cAMP-mediated signaling Source: UniProtKB

Cellular Location

Cell membrane; Endosome membrane. Colocalizes with ARRB2 in the endosome (PubMed:28827538).

Topology

Extracellular: 1-18
Helical: 19-39
Cytoplasmic: 40-53
Helical: 54-74
Extracellular: 75-91
Helical: 92-112
Cytoplasmic: 113-129
Helical: 130-150
Extracellular: 151-177
Helical: 178-198
Cytoplasmic: 199-239
Helical: 240-260
Extracellular: 261-272
Helical: 273-293
Cytoplasmic: 294-368

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Anti-GPR62 antibodies

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Rabbit Anti-GPR62 Recombinant Antibody (EG1405) (CBMAB-EN1684-LY)

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Target: GPR62

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1405

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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