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GPR62

Full Name
G protein-coupled receptor 62
Function
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538).

Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
Biological Process
G protein-coupled receptor signaling pathway Source: UniProtKB
Inositol phosphate-mediated signaling Source: UniProtKB
Positive regulation of cAMP-mediated signaling Source: UniProtKB
Cellular Location
Cell membrane; Endosome membrane. Colocalizes with ARRB2 in the endosome (PubMed:28827538).
Topology
Extracellular: 1-18
Helical: 19-39
Cytoplasmic: 40-53
Helical: 54-74
Extracellular: 75-91
Helical: 92-112
Cytoplasmic: 113-129
Helical: 130-150
Extracellular: 151-177
Helical: 178-198
Cytoplasmic: 199-239
Helical: 240-260
Extracellular: 261-272
Helical: 273-293
Cytoplasmic: 294-368
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Anti-GPR62 antibodies

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Rabbit Anti-GPR62 Recombinant Antibody (EG1405) (CBMAB-EN1684-LY)

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Target: GPR62
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1405
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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