GPR62

Full Name

G protein-coupled receptor 62

Function

Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538).

Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538).

Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).

Biological Process

G protein-coupled receptor signaling pathway Source: UniProtKB
Inositol phosphate-mediated signaling Source: UniProtKB
Positive regulation of cAMP-mediated signaling Source: UniProtKB

Cellular Location

Cell membrane; Endosome membrane. Colocalizes with ARRB2 in the endosome (PubMed:28827538).

Topology

Extracellular: 1-18
Helical: 19-39
Cytoplasmic: 40-53
Helical: 54-74
Extracellular: 75-91
Helical: 92-112
Cytoplasmic: 113-129
Helical: 130-150
Extracellular: 151-177
Helical: 178-198
Cytoplasmic: 199-239
Helical: 240-260
Extracellular: 261-272
Helical: 273-293
Cytoplasmic: 294-368

Anti-GPR62 antibodies

Rabbit Anti-GPR62 Recombinant Antibody (EG1405) (CBMAB-EN1684-LY)

Datasheet

SDS

Target: GPR62

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1405

Application*: WB: 1:500~1:1000 ELISA: 1:20000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)