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Rabbit Anti-GPR62 Recombinant Antibody (EG1405) (CBMAB-EN1684-LY)

The product is antibody recognizes GPR62. The antibody EG1405 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all GPR62 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1405
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR62.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 62
Entrez Gene ID
118442
UniProt ID
Q9BZJ7
Alternative Names
GPCR8; KPG_005
Function
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538).

Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538).

Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
Biological Process
G protein-coupled receptor signaling pathway Source: UniProtKB
Inositol phosphate-mediated signaling Source: UniProtKB
Positive regulation of cAMP-mediated signaling Source: UniProtKB
Cellular Location
Cell membrane; Endosome membrane. Colocalizes with ARRB2 in the endosome (PubMed:28827538).
Topology
Extracellular: 1-18
Helical: 19-39
Cytoplasmic: 40-53
Helical: 54-74
Extracellular: 75-91
Helical: 92-112
Cytoplasmic: 113-129
Helical: 130-150
Extracellular: 151-177
Helical: 178-198
Cytoplasmic: 199-239
Helical: 240-260
Extracellular: 261-272
Helical: 273-293
Cytoplasmic: 294-368
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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