Rabbit Anti-GPR62 Recombinant Antibody (EG1405) (CBMAB-EN1684-LY)

Name: Rabbit Anti-GPR62 Recombinant Antibody (EG1405)
SKU: CBMAB-EN1684-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1405

Application

WB: 1:500~1:1000 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GPR62.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G protein-coupled receptor 62

Entrez Gene ID

118442

UniProt ID

Q9BZJ7

Alternative Names

GPCR8; KPG_005

Function

Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538).

Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).

Biological Process

G protein-coupled receptor signaling pathway Source: UniProtKB
Inositol phosphate-mediated signaling Source: UniProtKB
Positive regulation of cAMP-mediated signaling Source: UniProtKB

Cellular Location

Cell membrane; Endosome membrane. Colocalizes with ARRB2 in the endosome (PubMed:28827538).

Topology

Extracellular: 1-18
Helical: 19-39
Cytoplasmic: 40-53
Helical: 54-74
Extracellular: 75-91
Helical: 92-112
Cytoplasmic: 113-129
Helical: 130-150
Extracellular: 151-177
Helical: 178-198
Cytoplasmic: 199-239
Helical: 240-260
Extracellular: 261-272
Helical: 273-293
Cytoplasmic: 294-368

Hay, C. M., Jackson, S., Mitew, S., Scott, D. J., Koenning, M., Bensen, A. L., ... & Emery, B. (2021). The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination. Neural Development, 16, 1-13.

Watkins, L. R., & Orlandi, C. (2020). Orphan G protein coupled receptors in affective disorders. Genes, 11(6), 694.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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