GPR65

Full Name

G protein-coupled receptor 65

Function

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421).

Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411).

May have a role in activation-induced cell death or differentiation of T-cells (By similarity).

Biological Process

Actin cytoskeleton reorganization Source: BHF-UCL
Activation of GTPase activity Source: BHF-UCL
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Apoptotic process Source: ProtInc
G protein-coupled receptor signaling pathway Source: BHF-UCL
Immune response Source: ProtInc
Multicellular organism development Source: ProtInc
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central
Positive regulation of stress fiber assembly Source: BHF-UCL
Response to acidic pH Source: BHF-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 1-15
Helical: 16-36
Cytoplasmic: 37-50
Helical: 51-71
Extracellular: 72-89
Helical: 90-110
Cytoplasmic: 111-129
Helical: 130-150
Extracellular: 151-180
Helical: 181-201
Cytoplasmic: 202-227
Helical: 228-248
Extracellular: 249-273
Helical: 274-294
Cytoplasmic: 295-337