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GPX5

This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Full Name

glutathione peroxidase 5 (epididymal androgen-related protein)

Function

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Biological Process

Cellular response to oxidative stress Source: Reactome
Lipid metabolic process Source: ProtInc

Cellular Location

Secreted

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Anti-GPX5 antibodies

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Mouse Anti-GPX5 Recombinant Antibody (CBLG1-1689) (CBMAB-G4761-LY)

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Target: GPX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBLG1-1689

Application*: WB, F, IF

Mouse Anti-GPX5 Recombinant Antibody (3B9) (CBMAB-G4760-LY)

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Target: GPX5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3B9

Application*: E, IP

Mouse Anti-GPX5 Recombinant Antibody (23B1) (V2LY-0226-LY985)

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Target: GPX5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 23B1

Application*: E, IP, IF, WB

Mouse Anti-GPX5 Recombinant Antibody (CBLG1-1680) (V2LY-0226-LY984)

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Target: GPX5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Mouse, Rat

Clone: CBLG1-1680

Application*: E, IP, IF, WB

Mouse Anti-GPX5 Recombinant Antibody (CBLG1-1679) (V2LY-0226-LY983)

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Target: GPX5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-1679

Application*: E, IP, IF, WB, P

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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