GSDMA

Full Name

gasdermin A

Function

Gasdermin-A:
This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death.

Gasdermin-A, N-terminal:
Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216).

Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids (PubMed:27281216).

Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216).

Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:27281216).

The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (PubMed:27281216).

Biological Process

Apoptotic process Source: UniProtKB
Defense response to bacterium Source: GO_Central
Pyroptosis Source: GO_Central

Cellular Location

Gasdermin-A: Cytosol; Perinuclear region
Gasdermin-A, N-terminal: Cell membrane

PTM

Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-A, N-terminal) that initiates pyroptosis.