HCAR3

HCAR3 (Hydroxycarboxylic Acid Receptor 3) is a Protein Coding gene. Diseases associated with HCAR3 include Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is HCAR2.

Full Name

hydroxycarboxylic acid receptor 3

Function

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

Biological Process

G protein-coupled receptor signaling pathway Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-28
Helical: 29-50
Cytoplasmic: 51-63
Helical: 64-85
Extracellular: 86-102
Helical: 103-123
Cytoplasmic: 124-142
Helical: 143-163
Extracellular: 164-194
Helical: 195-209
Cytoplasmic: 210-236
Helical: 237-256
Extracellular: 257-273
Helical: 274-298
Cytoplasmic: 299-387