HENMT1

HENMT1 (HEN Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and RNA methyltransferase activity.

Full Name

HEN Methyltransferase 1

Function

Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

Biological Process

piRNA metabolic process Source: UniProtKB
Production of siRNA involved in RNA interference Source: GO_Central
RNA methylation Source: FlyBase

Cellular Location

Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.

Anti-HENMT1 antibodies

Mouse Anti-HENMT1 (AA 36-135) Recombinant Antibody (CBFYH-3554) (CBMAB-H4107-FY)

Datasheet

SDS

Target: HENMT1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-3554

Application*: E, IC, IF, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)