HES5

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq]

hairy and enhancer of split 5 (Drosophila)

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).

Anterior/posterior pattern specification Source: GO_Central
Astrocyte differentiation Source: UniProtKB
Brain development Source: UniProtKB
Camera-type eye development Source: UniProtKB
Cartilage development Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell maturation Source: UniProtKB
Central nervous system myelination Source: UniProtKB
Comma-shaped body morphogenesis Source: Ensembl
Establishment of epithelial cell polarity Source: Ensembl
Forebrain radial glial cell differentiation Source: Ensembl
Glial cell fate commitment Source: UniProtKB
Inner ear receptor cell stereocilium organization Source: Ensembl
Metanephric nephron tubule morphogenesis Source: Ensembl
Negative regulation of astrocyte differentiation Source: UniProtKB
Negative regulation of forebrain neuron differentiation Source: Ensembl
Negative regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Negative regulation of neuron differentiation Source: UniProtKB
Negative regulation of oligodendrocyte differentiation Source: UniProtKB
Negative regulation of pro-B cell differentiation Source: UniProtKB
Negative regulation of stem cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Neural tube development Source: UniProtKB
Neuronal stem cell population maintenance Source: UniProtKB
Notch signaling pathway Source: UniProtKB
Oligodendrocyte development Source: UniProtKB
Positive regulation of BMP signaling pathway Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of Notch signaling pathway Source: Ensembl
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Protein-containing complex assembly Source: UniProtKB
Regulation of cell differentiation Source: UniProtKB
Regulation of epithelial cell proliferation Source: Ensembl
Regulation of myelination Source: UniProtKB
Regulation of neurogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Smoothened signaling pathway Source: UniProtKB
Specification of loop of Henle identity Source: Ensembl
S-shaped body morphogenesis Source: Ensembl
Telencephalon development Source: UniProtKB

Nucleus