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HIPK4

This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53.

Full Name

homeodomain interacting protein kinase 4

Function

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity).

May act as a corepressor of transcription factors (Potential).

Biological Process

Histone phosphorylation Source: Ensembl
Peptidyl-serine phosphorylation Source: GO_Central
Peptidyl-threonine phosphorylation Source: GO_Central
Protein autophosphorylation Source: Ensembl
Regulation of signal transduction by p53 class mediator Source: Ensembl

Cellular Location

Cytoplasm

PTM

Autophosphorylated.

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Anti-HIPK4 antibodies

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Mouse Anti-HIPK4 Recombinant Antibody (2E8) (CBMAB-A3914-LY)

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Target: HIPK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2E8

Application*: WB, E

Mouse Anti-HIPK4 Monoclonal Antibody (CBFYH-3072) (CBMAB-H2088-FY)

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Target: HIPK4

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: CBFYH-3072

Application*: WB, E

Mouse Anti-HIPK4 Recombinant Antibody (CBFYH-1135) (CBMAB-H0682-FY)

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Target: HIPK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-1135

Application*: E, WB

Human Recombinant HIPK4, Active protein, His Tag (V2LY-0526-LY4550)

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Target: HIPK4

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: His Tag

Human Recombinant HIPK4, Active protein, GST Tag (V2LY-0526-LY4549)

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Target: HIPK4

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Rabbit Anti-HIPK4 Recombinant Antibody (EG1513) (CBMAB-EN1808-LY)

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Target: HIPK4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1513

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:00~1:500 ELISA: 1:20000

HIPK4 Matched Antibody Pair (543) (APMAB-543LY)

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Target: HIPK4

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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