Mouse Anti-HIPK4 Recombinant Antibody (CBFYH-1135) (CBMAB-H0682-FY)

Name: Mouse Anti-HIPK4 Recombinant Antibody (CBFYH-1135)
SKU: CBMAB-H0682-FY
Rating: 5 (1 reviews)

See all HIPK4 antibodies

Online Inquiry

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-1135

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

homeodomain interacting protein kinase 4

Introduction

This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53.

Entrez Gene ID

147746

UniProt ID

Q8NE63

Alternative Names

Homeodomain Interacting Protein Kinase 4; EC 2.7.11.

Function

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity).

May act as a corepressor of transcription factors (Potential).

Biological Process

Histone phosphorylation Source: Ensembl
Peptidyl-serine phosphorylation Source: GO_Central
Peptidyl-threonine phosphorylation Source: GO_Central
Protein autophosphorylation Source: Ensembl
Regulation of signal transduction by p53 class mediator Source: Ensembl

Cellular Location

Cytoplasm

PTM

Autophosphorylated.

More Infomation

References

Liu, X., Zang, C., Wu, Y., Meng, R., Chen, Y., Jiang, T., ... & Guo, X. (2022). Homeodomain-interacting protein kinase HIPK4 regulates phosphorylation of manchette protein RIMBP3 during spermiogenesis. Journal of Biological Chemistry, 298(9).

Crapster, J. A., Rack, P. G., Hellmann, Z. J., Le, A. D., Adams, C. M., Leib, R. D., ... & Chen, J. K. (2020). HIPK4 is essential for murine spermiogenesis. elife, 9, e50209.

Aaron, C. J., Rack, P. G., Hellmann, Z. J., Le, A. D., Adams, C. M., Leib, R. D., ... & Chen, J. K. (2020). HIPK4 is essential for murine spermiogenesis. eLife, 9.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-HIPK4 Recombinant Antibody (CBFYH-1135)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

HIPK4 Matched Antibody Pair (543)

Related Products

Mouse Anti-HIPK4 Recombinant Antibody (2E8)

HIPK4 Matched Antibody Pair (543)

Mouse Anti-HIPK4 Monoclonal Antibody (CBFYH-3072)

Rabbit Anti-HIPK4 Recombinant Antibody (EG1513)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: