HMGCS1

HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) is a Protein Coding gene. Among its related pathways are Terpenoid backbone biosynthesis and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and isomerase activity. An important paralog of this gene is HMGCS2.

Full Name

3-Hydroxy-3-Methylglutaryl-CoA Synthase 1

Function

Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.

Biological Process

Acetyl-CoA metabolic process Source: GO_Central
Cholesterol biosynthetic process Source: Reactome
Farnesyl diphosphate biosynthetic process, mevalonate pathway Source: GO_Central
Lipid metabolic process Source: ProtInc

Cellular Location

Cytoplasm

Anti-HMGCS1 antibodies

Rabbit Anti-HMGCS1 Recombinant Antibody (D1Q9D) (CBMAB-CP1035-LY)

Datasheet

SDS

Target: HMGCS1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D1Q9D

Application*: WB, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)