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Rabbit Anti-HMGCS1 Recombinant Antibody (D1Q9D) (CBMAB-CP1035-LY)

The product is antibody recognizes HMGCS1. The antibody D1Q9D immunoassay techniques such as: WB,IP.
See all HMGCS1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D1Q9D
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu483 of human HMGCS1 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
3-Hydroxy-3-Methylglutaryl-CoA Synthase 1
Introduction
HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) is a Protein Coding gene. Among its related pathways are Terpenoid backbone biosynthesis and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and isomerase activity. An important paralog of this gene is HMGCS2.
Entrez Gene ID
Human3157
Mouse208715
Rat29637
Monkey702553
UniProt ID
HumanQ01581
MouseQ8JZK9
RatP17425
MonkeyF7HQ90
Alternative Names
3-Hydroxy-3-Methylglutaryl-CoA Synthase 1; 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase 1 (Soluble); 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Synthase; 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble); EC 2.3.3.10; HMGCS; Hydroxymethylglutaryl-CoA Synthase; Cytoplasmic; 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase; HMG-CoA Synthase;
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
Biological Process
Acetyl-CoA metabolic process Source: GO_Central
Cholesterol biosynthetic process Source: Reactome
Farnesyl diphosphate biosynthetic process, mevalonate pathway Source: GO_Central
Lipid metabolic process Source: ProtInc
Cellular Location
Cytoplasm

Zhang, X., Sun, C., Wan, J., Zhang, X., Jia, Y., & Zhou, C. (2023). Compartmentalized activities of HMGCS1 control cervical cancer radiosensitivity. Cellular Signalling, 101, 110507.

Ma, X., Bai, Y., Liu, K., Han, Y., Zhang, J., Liu, Y., ... & Bai, G. (2022). Ursolic acid inhibits the cholesterol biosynthesis and alleviates high fat diet-induced hypercholesterolemia via irreversible inhibition of HMGCS1 in vivo. Phytomedicine, 103, 154233.

Xu, C., Zhuo, Y., Liu, Y., & Chen, H. (2022). Itraconazole inhibits the growth of cutaneous squamous cell carcinoma by targeting HMGCS1/ACSL4 axis. Frontiers in Pharmacology, 13, 828983.

Ying, X., Zhu, Y., Jin, X., & Chang, X. (2021). Umbilical cord plasma-derived exosomes from preeclamptic women induce vascular dysfunction by targeting HMGCS1 in endothelial cells. Placenta, 103, 86-93.

Yao, W., Jiao, Y., Zhou, Y., & Luo, X. (2020). KLF13 suppresses the proliferation and growth of colorectal cancer cells through transcriptionally inhibiting HMGCS1-mediated cholesterol biosynthesis. Cell & bioscience, 10(1), 1-10.

Zhang, J., Jiang, M., Qian, L., Lin, X., Song, W., Gao, Y., & Zhou, Y. (2020). The STAT3‐miR‐223‐TGFBR3/HMGCS1 axis modulates the progression of cervical carcinoma. Molecular oncology, 14(9), 2313-2331.

He, J., Zhao, H., Liu, X., Wang, D., Wang, Y., Ai, Y., & Yang, J. (2020). Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome‑mediated circ‑HMGCS1 via the miR‑34a‑5p/SGPP1 axis. Oncology Reports, 44(6), 2429-2442.

Wang, I. H., Huang, T. T., Chen, J. L., Chu, L. W., Ping, Y. H., Hsu, K. W., ... & Yeh, T. S. (2020). Mevalonate pathway enzyme HMGCS1 contributes to gastric cancer progression. Cancers, 12(5), 1088.

Walsh, C. A., Akrap, N., Garre, E., Magnusson, Y., Harrison, H., Andersson, D., ... & Landberg, G. (2020). The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer. PLoS One, 15(7), e0236187.

Zhou, S., Xu, H., Tang, Q., Xia, H., & Bi, F. (2020). Dipyridamole enhances the cytotoxicities of trametinib against colon cancer cells through combined targeting of HMGCS1 and MEK pathway. Molecular cancer therapeutics, 19(1), 135-146.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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