HMGN5
This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein.
Full Name
High Mobility Group Nucleosome Binding Domain 5
Function
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
Biological Process
Chromatin organization Source: UniProtKB-KW
Negative regulation of apoptotic process Source: CACAO
Positive regulation of cell population proliferation Source: CACAO
Positive regulation of gene expression Source: CACAO
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of apoptotic process Source: CACAO
Positive regulation of cell population proliferation Source: CACAO
Positive regulation of gene expression Source: CACAO
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleus. Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
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Anti-HMGN5 antibodies
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Target: HMGN5
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 2E6
Application*: IP, WB, M
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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