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HMGN5

This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein.

Full Name

High Mobility Group Nucleosome Binding Domain 5

Function

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.

Biological Process

Chromatin organization Source: UniProtKB-KW
Negative regulation of apoptotic process Source: CACAO
Positive regulation of cell population proliferation Source: CACAO
Positive regulation of gene expression Source: CACAO
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleus. Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.

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Anti-HMGN5 antibodies

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Mouse Anti-HMGN5 Antibody (2E6) (CBMAB-0488-YC)

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Target: HMGN5

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 2E6

Application*: IP, WB, M

Mouse Anti-HMGN5 Antibody (2E6)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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