HOXD9

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq]

Full Name

HOXD9

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: GO_Central
Embryonic forelimb morphogenesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hindlimb morphogenesis Source: Ensembl
Mammary gland development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Peripheral nervous system neuron development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Proximal/distal pattern formation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Single fertilization Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus