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Mouse Anti-HOXD9 Recombinant Antibody (2A9) (CBMAB-A4083-LY)

The product is antibody recognizes HOXD9. The antibody 2A9 immunoassay techniques such as: WB, ELISA.
See all HOXD9 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2A9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXD9 (NP_055028, 146 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
HOXD9
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq]
Entrez Gene ID
Human3235
Mouse15438
UniProt ID
HumanP28356
MouseP28357
Alternative Names
HOX4; HOX4C; Hox-4.3; Hox-5.2
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: GO_Central
Embryonic forelimb morphogenesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hindlimb morphogenesis Source: Ensembl
Mammary gland development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Peripheral nervous system neuron development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Proximal/distal pattern formation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Single fertilization Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Transcription, DNA-templated Source: InterPro
Cellular Location
Nucleus

Li, J., Pei, M., Xiao, W., Liu, X., Hong, L., Yu, Z., ... & Wang, J. (2023). The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation. Cell Death & Disease, 14(5), 341.

Hu, X. C., Chu, J., Zhou, Y., Li, C. C., Zhou, G. J., & Jiang, G. Q. (2022). HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3. Cellular Signalling, 90, 110188.

Chang, J., Hu, X., Nan, J., Zhang, X., & Jin, X. (2021). HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation. Molecular Medicine Reports, 24(5), 1-11.

Lin, L. F., Li, Y. T., Han, H., & Lin, S. G. (2021). MicroRNA-205-5p targets the HOXD9-Snail1 axis to inhibit triple negative breast cancer cell proliferation and chemoresistance. Aging (Albany NY), 13(3), 3945.

Wen, D., Wang, L., Tan, S., Tang, R., Xie, W., Liu, S., ... & He, Y. (2020). HOXD9 aggravates the development of cervical cancer by transcriptionally activating HMCN1. Panminerva Medica, 64(4), 532-536.

Liu, M., Xiao, Y., Tang, W., Li, J., Hong, L., Dai, W., ... & Xiang, L. (2020). HOXD9 promote epithelial‐mesenchymal transition and metastasis in colorectal carcinoma. Cancer Medicine, 9(11), 3932-3943.

Kishibuchi, R., Kondo, K., Soejima, S., Tsuboi, M., Kajiura, K., Kawakami, Y., ... & Tangoku, A. (2020). DNA methylation of GHSR, GNG4, HOXD9 and SALL3 is a common epigenetic alteration in thymic carcinoma. International Journal of Oncology, 56(1), 315-326.

Xiong, R., Yin, T., Gao, J. L., & Yuan, Y. F. (2020). HOXD9 activates the TGF-β/Smad signaling pathway to promote gastric cancer. OncoTargets and therapy, 2163-2172.

Zhu, H., Dai, W., Li, J., Xiang, L., Wu, X., Tang, W., ... & Wang, J. (2019). HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3. Journal of Experimental & Clinical Cancer Research, 38, 1-15.

Wasenang, W., Chaiyarit, P., Proungvitaya, S., & Limpaiboon, T. (2019). Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary diseases. Clinical Epigenetics, 11(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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