Mouse Anti-HOXD9 (AA 146-210) Recombinant Antibody (CBFYH-1856) (CBMAB-H2862-FY)

Name: Mouse Anti-HOXD9 (AA 146-210) Recombinant Antibody (CBFYH-1856)
SKU: CBMAB-H2862-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-1856

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: RHYGIKPETR AAPAPATAAS TTSSSSTSLS SSSKRTECSV ARESQGSSGP EFSCNSFLQE KAAA*

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 146-210

More Infomation

Target

Full Name

HOXD9

Introduction

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.

Entrez Gene ID

3235

UniProt ID

P28356

Alternative Names

Homeobox D9; Homeobox Protein Hox-5.2; Homeobox Protein Hox-4C; Homeo Box D9; HOX4C; Hox-4.3, Mouse, Homolog Of

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: GO_Central
Embryonic forelimb morphogenesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hindlimb morphogenesis Source: Ensembl
Mammary gland development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Peripheral nervous system neuron development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Proximal/distal pattern formation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Single fertilization Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus

Li, J., Pei, M., Xiao, W., Liu, X., Hong, L., Yu, Z., ... & Wang, J. (2023). The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation. Cell Death & Disease, 14(5), 341.

Hu, X. C., Chu, J., Zhou, Y., Li, C. C., Zhou, G. J., & Jiang, G. Q. (2022). HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3. Cellular Signalling, 90, 110188.

Chang, J., Hu, X., Nan, J., Zhang, X., & Jin, X. (2021). HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation. Molecular Medicine Reports, 24(5), 1-11.

Lin, L. F., Li, Y. T., Han, H., & Lin, S. G. (2021). MicroRNA-205-5p targets the HOXD9-Snail1 axis to inhibit triple negative breast cancer cell proliferation and chemoresistance. Aging (Albany NY), 13(3), 3945.

Wen, D., Wang, L., Tan, S., Tang, R., Xie, W., Liu, S., ... & He, Y. (2020). HOXD9 aggravates the development of cervical cancer by transcriptionally activating HMCN1. Panminerva Medica, 64(4), 532-536.

Liu, M., Xiao, Y., Tang, W., Li, J., Hong, L., Dai, W., ... & Xiang, L. (2020). HOXD9 promote epithelial‐mesenchymal transition and metastasis in colorectal carcinoma. Cancer Medicine, 9(11), 3932-3943.

Kishibuchi, R., Kondo, K., Soejima, S., Tsuboi, M., Kajiura, K., Kawakami, Y., ... & Tangoku, A. (2020). DNA methylation of GHSR, GNG4, HOXD9 and SALL3 is a common epigenetic alteration in thymic carcinoma. International Journal of Oncology, 56(1), 315-326.

Xiong, R., Yin, T., Gao, J. L., & Yuan, Y. F. (2020). HOXD9 activates the TGF-β/Smad signaling pathway to promote gastric cancer. OncoTargets and therapy, 2163-2172.

Zhu, H., Dai, W., Li, J., Xiang, L., Wu, X., Tang, W., ... & Wang, J. (2019). HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3. Journal of Experimental & Clinical Cancer Research, 38, 1-15.

Wasenang, W., Chaiyarit, P., Proungvitaya, S., & Limpaiboon, T. (2019). Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary diseases. Clinical Epigenetics, 11(1), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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