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HS3ST4

This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis.

Full Name

Heparan Sulfate-Glucosamine 3-Sulfotransferase 4

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).

Biological Process

Heparan sulfate proteoglycan metabolic process Source: UniProtKB

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-34
Helical: 35-59
Lumenal: 60-456

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Anti-HS3ST4 antibodies

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Mouse Anti-HS3ST4 Recombinant Antibody (CBFYH-1979) (CBMAB-H2990-FY)

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Target: HS3ST4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-1979

Application*: P, IP

Mouse Anti-HS3ST4 (AA 184-456) Recombinant Antibody (CBFYH-1981) (CBMAB-H2992-FY)

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Target: HS3ST4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-1981

Application*: IH, IP

Mouse Anti-HS3ST4 Monoclonal Antibody (CBFYH-3205) (CBMAB-H2989-FY)

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Target: HS3ST4

Host: Mouse

Antibody Isotype: IgG2

Specificity: Mouse, Human

Clone: CBFYH-3205

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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