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HSPB6

This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]
Full Name
Heat Shock Protein Family B (Small) Member 6
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Biological Process
Chaperone-mediated protein folding Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Cellular Location
Nucleus; Secreted; Cytoplasm. Translocates to nuclear foci during heat shock.
PTM
The N-terminus is blocked.
Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.

Anti-HSPB6 antibodies

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Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2387) (CBMAB-H3400-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2387
Application*: E, IF, P, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2386) (CBMAB-H3399-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Human
Clone: CBFYH-2386
Application*: WB, E, P, IF

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2382) (CBMAB-H3395-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2382
Application*: E, IF, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2381) (CBMAB-H3394-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYH-2381
Application*: IH, IC, IF, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2380) (CBMAB-H3393-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYH-2380
Application*: IH, E, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2379) (CBMAB-H3392-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBFYH-2379
Application*: E, IF, P, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2378) (CBMAB-H3391-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2378
Application*: E, IF, P, WB

Mouse Anti-HSPB6 (AA 1-162) Recombinant Antibody (CBFYH-2377) (CBMAB-H3390-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYH-2377
Application*: E, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2373) (CBMAB-H3388-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2373
Application*: E, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2375) (CBMAB-H0747-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBFYH-2375
Application*: E, WB

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2376) (CBMAB-H0746-FY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2376
Application*: E, IF, WB

Mouse Anti-HSPB6 Recombinant Antibody (D4) (CBMAB-AP2729LY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: D4
Application*: ICC, IHC, IP, WB

Mouse Anti-HSPB6 Recombinant Antibody (CAP902) (CBMAB-AP2728LY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP902
Application*: ICC, IHC, IP, WB

Mouse Anti-HSPB6 Recombinant Antibody (6A4) (CBMAB-A4133-LY)

Datasheet SDS
Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 6A4
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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