HSPB6

This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]
Full Name
Heat Shock Protein Family B (Small) Member 6
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Biological Process
Chaperone-mediated protein folding Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Cellular Location
Nucleus; Secreted; Cytoplasm. Translocates to nuclear foci during heat shock.
PTM
The N-terminus is blocked.
Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.
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Anti-HSPB6 antibodies

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Mouse Anti-HSPB6 Recombinant Antibody (6A4) (CBMAB-A4133-LY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 6A4
Application*: WB, E
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (D4) (CBMAB-AP2729LY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: D4
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CAP902) (CBMAB-AP2728LY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP902
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2387) (CBMAB-H3400-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2387
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2386) (CBMAB-H3399-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Human
Clone: CBFYH-2386
Application*: WB, E, P, IF
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2382) (CBMAB-H3395-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2382
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2381) (CBMAB-H3394-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYH-2381
Application*: IH, IC, IF, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2380) (CBMAB-H3393-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYH-2380
Application*: IH, E, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2379) (CBMAB-H3392-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBFYH-2379
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2378) (CBMAB-H3391-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2378
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-HSPB6 (AA 1-162) Recombinant Antibody (CBFYH-2377) (CBMAB-H3390-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYH-2377
Application*: E, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2373) (CBMAB-H3388-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2373
Application*: E, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2375) (CBMAB-H0747-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBFYH-2375
Application*: E, WB
Datasheet SDS

Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2376) (CBMAB-H0746-FY)

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Target: HSPB6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2376
Application*: E, IF, WB
Datasheet SDS

Human HSPB6 ELISA Kit (V2LY-0626-LY4653)

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Target: HSPB6
Sensitivity: 0.022 ng/mL
Detection Range: 0.05-10 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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