Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2380) (CBMAB-H3393-FY)

Name: Mouse Anti-HSPB6 Recombinant Antibody (CBFYH-2380)
SKU: CBMAB-H3393-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2380

Application

IHC, ELISA, WB

Immunogen

Raised against HSPb6 conjugated to biotin

Specificity

Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Heat Shock Protein Family B (Small) Member 6

Introduction

This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation.

Entrez Gene ID

192245

UniProt ID

P97541

Alternative Names

p20; Hsp20

Function

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.

Biological Process

Chaperone-mediated protein folding Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB

Cellular Location

Nucleus; Secreted; Cytoplasm. Translocates to nuclear foci during heat shock.

PTM

The N-terminus is blocked.
Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.

Almutairi, B. O., Almutairi, M. H., Alrefaei, A. F., Alkahtani, S., & Alarifi, S. (2023). HSPB6 Is Depleted in Colon Cancer Patients and Its Expression Is Induced by 5-aza-2′-Deoxycytidine In Vitro. Medicina, 59(5), 996.

Pfeffer, T. J., Auber, B., Pabst, B., Agca, K. C., Berliner, D., König, T., ... & Ricke-Hoch, M. (2023). Prevalence of HSPB6 gene variants in peripartum cardiomyopathy: Data from the German PPCM registry. International Journal of Cardiology, 379, 96-99.

Kumar, R., Gupta, I. D., Verma, A., Singh, S., Kumari, R., & Verma, N. (2022). Genetic polymorphism in HSPB6 gene and their association with heat tolerance traits in Indian Karan Fries (Bos taurus x Bos indicus) cattle. Animal Biotechnology, 33(7), 1416-1427.

Shatov, V. M., & Gusev, N. B. (2020). Physico-chemical properties of two point mutants of small heat shock protein HspB6 (Hsp20) with abrogated cardioprotection. Biochimie, 174, 126-135.

Mikhaylova, V. V., Eronina, T. B., Chebotareva, N. A., Shubin, V. V., Kalacheva, D. I., & Kurganov, B. I. (2020). Effect of arginine on chaperone-like activity of HspB6 and monomeric 14-3-3ζ. International journal of molecular sciences, 21(6), 2039.

Qi, A. Q., Zhang, Y. H., Qi, Q. D., Liu, Y. H., & Zhu, J. L. (2019). Overexpressed HspB6 underlines a novel inhibitory role in kainic acid-induced epileptic seizure in rats by activating the cAMP-PKA pathway. Cellular and Molecular Neurobiology, 39, 111-122.

Shatov, V. M., Weeks, S. D., Strelkov, S. V., & Gusev, N. B. (2018). The role of the arginine in the conserved N-terminal domain RLFDQxFG motif of human small heat shock proteins HspB1, HspB4, HspB5, HspB6, and HspB8. International Journal of Molecular Sciences, 19(7), 2112.

Liu, G. S., Zhu, H., Cai, W. F., Wang, X., Jiang, M., Essandoh, K., ... & Kranias, E. G. (2018). Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant. Autophagy, 14(1), 80-97.

Li, F., Xiao, H., Zhou, F., Hu, Z., & Yang, B. (2018). Study of HSPB6: insights into the properties of the multifunctional protective agent. Cellular Physiology and Biochemistry, 44(1), 314-332.

Ferreira, L. A., Gusev, N. B., Uversky, V. N., & Zaslavsky, B. Y. (2018). Effect of human heat shock protein HspB6 on the solvent features of water in aqueous solutions. Journal of Biomolecular Structure and Dynamics, 36(6), 1520-1528.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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