HTR6

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor.

Full Name

5-hydroxytryptamine receptor 6

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity).

Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).

Is an activator of TOR signaling (PubMed:23027611).

Biological Process

Cerebral cortex cell migration Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Positive regulation of TOR signaling Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-34
Helical: 35-57
Cytoplasmic: 58-64
Helical: 65-85
Extracellular: 86-100
Helical: 101-122
Cytoplasmic: 123-144
Helical: 145-166
Extracellular: 167-184
Helical: 185-208
Cytoplasmic: 209-265
Helical: 266-290
Extracellular: 291-295
Helical: 296-320
Cytoplasmic: 321-440