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Rabbit Anti-HTR6 Recombinant Antibody (EG1594) (CBMAB-EN1907-LY)

The product is antibody recognizes HTR6. The antibody EG1594 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all HTR6 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1594
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human 5-HT-6.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
5-hydroxytryptamine receptor 6
Introduction
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor.
Entrez Gene ID
Human3362
Mouse15565
Rat64354
UniProt ID
HumanP50406
MouseQ9R1C8
RatP31388
Alternative Names
5-HT6; 5-HT6R
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity).

Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).

Is an activator of TOR signaling (PubMed:23027611).
Biological Process
Cerebral cortex cell migration Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Positive regulation of TOR signaling Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-34
Helical: 35-57
Cytoplasmic: 58-64
Helical: 65-85
Extracellular: 86-100
Helical: 101-122
Cytoplasmic: 123-144
Helical: 145-166
Extracellular: 167-184
Helical: 185-208
Cytoplasmic: 209-265
Helical: 266-290
Extracellular: 291-295
Helical: 296-320
Cytoplasmic: 321-440
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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