Rabbit Anti-HTR6 Recombinant Antibody (EG1594) (CBMAB-EN1907-LY)

Name: Rabbit Anti-HTR6 Recombinant Antibody (EG1594)
SKU: CBMAB-EN1907-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1594

Application

WB: 1:500~1:1000 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human 5-HT-6.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

5-hydroxytryptamine receptor 6

Introduction

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor.

Entrez Gene ID

Human	3362
Mouse	15565
Rat	64354

UniProt ID

Human	P50406
Mouse	Q9R1C8
Rat	P31388

Alternative Names

5-HT6; 5-HT6R

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity).

Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).

Is an activator of TOR signaling (PubMed:23027611).

Biological Process

Cerebral cortex cell migration Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Positive regulation of TOR signaling Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-34
Helical: 35-57
Cytoplasmic: 58-64
Helical: 65-85
Extracellular: 86-100
Helical: 101-122
Cytoplasmic: 123-144
Helical: 145-166
Extracellular: 167-184
Helical: 185-208
Cytoplasmic: 209-265
Helical: 266-290
Extracellular: 291-295
Helical: 296-320
Cytoplasmic: 321-440

Teng, L. L., Lu, G. L., Chiou, L. C., Lin, W. S., Cheng, Y. Y., Hsueh, T. E., ... & Wang, P. Y. (2019). Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction–induced memory enhancement. PLoS Biology, 17(3), e2007097.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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