ID4

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis.

Full Name

inhibitor of DNA binding 4, HLH protein

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).

Biological Process

Cell differentiation Source: GO_Central
Cellular protein localization Source: Ensembl
Central nervous system myelination Source: Ensembl
Cerebral cortex neuron differentiation Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Fat cell differentiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of fat cell differentiation Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Neuroblast proliferation Source: Ensembl
Osteoblast differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Prostate gland epithelium morphogenesis Source: Ensembl
Prostate gland stromal morphogenesis Source: Ensembl
Seminal vesicle morphogenesis Source: Ensembl

Cellular Location

Nucleus