ID4

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis.
Full Name
inhibitor of DNA binding 4, HLH protein
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).
Biological Process
Cell differentiation Source: GO_Central
Cellular protein localization Source: Ensembl
Central nervous system myelination Source: Ensembl
Cerebral cortex neuron differentiation Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Fat cell differentiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of fat cell differentiation Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Neuroblast proliferation Source: Ensembl
Osteoblast differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Prostate gland epithelium morphogenesis Source: Ensembl
Prostate gland stromal morphogenesis Source: Ensembl
Seminal vesicle morphogenesis Source: Ensembl
Cellular Location
Nucleus
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Anti-ID4 antibodies

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Mouse Anti-ID4 Antibody (3C6) (CBMAB-0527-YC)

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Target: ID4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3C6
Application*: IP, M
Datasheet SDS

Mouse Anti-ID4 Antibody (1A6) (CBMAB-0523-YC)

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Target: ID4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A6
Application*: IP, M
Datasheet SDS

Mouse Anti-ID4 Antibody (1A10) (CBMAB-0522-YC)

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Target: ID4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A10
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-ID4 Antibody (1A1) (CBMAB-0521-YC)

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Target: ID4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A1
Application*: IP, M
Datasheet SDS

Human ID4 ELISA Kit (V2LY-0626-LY4507)

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Target: ID4
Sensitivity: 0.0051 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rabbit Anti-ID4 Recombinant Antibody (EG1604) (CBMAB-EN1918-LY)

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Target: ID4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1604
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS

Mouse Anti-ID4 Recombinant Antibody (3F11) (CBMAB-A4218-LY)

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Target: ID4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F11
Application*: WB, E
Datasheet SDS

Mouse Anti-ID4 Recombinant Antibody (CBYY-I1996) (CBMAB-I3166-YY)

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Target: ID4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1996
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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