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IL1R2

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Full Name
Interleukin 1 Receptor Type 2
Function
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Biological Process
Immune response Source: ProtInc
Negative regulation of cytokine production involved in inflammatory response Source: Ensembl
Negative regulation of interleukin-1 alpha production Source: Ensembl
Negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Negative regulation of protein processing Source: Ensembl
Cellular Location
Isoform Short: Secreted
Isoform Long: Cell membrane
Topology
Extracellular: 14-343
Helical: 344-369
Cytoplasmic: 370-398
PTM
A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.

Anti-IL1R2 antibodies

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Mouse Anti-IL1R2 Recombinant Antibody (CBFYA-0093) (CBMAB-X0136-FY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYA-0093
Application*: IA

Mouse Anti-IL1R2 Recombinant Antibody (CBFYA-0092) (CBMAB-X0135-FY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0092
Application*: F, IA, WB

Mouse Anti-IL1R2 Recombinant Antibody (CBFYC-2758) (CBMAB-C2833-FY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2758
Application*: E, WB

Mouse Anti-IL1R2 Recombinant Antibody (CBYY-I2034) (CBMAB-I3204-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2034
Application*: WB

Mouse Anti-IL1R2 Recombinant Antibody (CBYY-I1300) (CBMAB-I2469-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYY-I1300
Application*: E

Rat Anti-IL1R2 Recombinant Antibody (CBYY-I1254) (CBMAB-I2423-YY)

Datasheet SDS
Target: IL1R2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1254
Application*: IH, WB

Mouse Anti-IL1R2 Recombinant Antibody (CBYY-I1146) (CBMAB-I2314-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1146
Application*: IH, WB

Mouse Anti-IL1R2 Recombinant Antibody (CBYY-I1145) (CBMAB-I2313-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1145
Application*: F, WB

Mouse Anti-IL1R2 Recombinant Antibody (CBYY-I0963) (CBMAB-I2131-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I0963
Application*: IH, N, WB

Mouse Anti-IL1R2 Recombinant Antibody (BDI204) (CBMAB-I1988-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BDI204
Application*: E, R, IF

Mouse Anti-IL1R2 Recombinant Antibody (9L836) (CBMAB-I1848-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9L836
Application*: F

Mouse Anti-IL1R2 Recombinant Antibody (7H4D4F8) (CBMAB-I1693-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H4D4F8
Application*: E

Mouse Anti-IL1R2 Recombinant Antibody (6D489) (CBMAB-I1562-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D489
Application*: E, WB, IH, F, IC

Mouse Anti-IL1R2 Recombinant Antibody (A519) (CBMAB-AP10854LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: A519
Application*: ELISA, IF, WB

Mouse Anti-IL1R2 Recombinant Antibody (CF231) (CBMAB-FT269LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF231
Application*: ELISA, WB, IF

Recombinant Mouse Anti-IL1R2 Antibody (CBHb150) (CBMAB-Hb580-LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBHb150
Application*: Immuno assays

Recombinant Mouse Anti-IL1R2 Antibody (CBHb149) (CBMAB-Hb578-LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb149
Application*: FC, Immuno assays, WB

Mouse Anti-IL1R2 Recombinant Antibody (MNC2) (CBMAB-C11684-LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MNC2
Application*: E, F

Mouse Anti-IL1R2 Recombinant Antibody (CBYY-C2565) (CBMAB-C4006-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2565
Application*: E

Mouse Anti-IL1R2 Recombinant Antibody (CBYY-C2562) (CBMAB-C4003-YY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2562
Application*: E, WB

Rat Anti-IL1R2 Recombinant Antibody (CBYY-C0274) (CBMAB-C0884-YY)

Datasheet SDS
Target: IL1R2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-C0274
Application*: F

Mouse Anti-IL1R2 Recombinant Antibody (6G5) (CBMAB-C8322-LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6G5
Application*: E

Mouse Anti-IL1R2 Recombinant Antibody (49/20) (CBMAB-C6526-LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 49/20
Application*: E, WB

Mouse Anti-IL1R2 Recombinant Antibody (3C6) (CBMAB-C5821-LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C6
Application*: WB

Mouse Anti-IL1R2 Recombinant Antibody (1G12) (CBMAB-C4142-LY)

Datasheet SDS
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G12
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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