IL1R2
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Full Name
Interleukin 1 Receptor Type 2
Function
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Biological Process
Immune response Source: ProtInc
Negative regulation of cytokine production involved in inflammatory response Source: Ensembl
Negative regulation of interleukin-1 alpha production Source: Ensembl
Negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Negative regulation of protein processing Source: Ensembl
Negative regulation of cytokine production involved in inflammatory response Source: Ensembl
Negative regulation of interleukin-1 alpha production Source: Ensembl
Negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Negative regulation of protein processing Source: Ensembl
Cellular Location
Isoform Short: Secreted
Isoform Long: Cell membrane
Isoform Long: Cell membrane
Topology
Extracellular: 14-343
Helical: 344-369
Cytoplasmic: 370-398
Helical: 344-369
Cytoplasmic: 370-398
PTM
A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
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Anti-IL1R2 antibodies
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CompareTarget: IL1R2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-C0274
Application*: F
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4736
Application*: WB, F
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3830
Application*: IC, F
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: A519
Application*: ELISA, IF, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF231
Application*: ELISA, WB, IF
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBHb150
Application*: Immuno assays
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb149
Application*: FC, Immuno assays, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MNC2
Application*: E, F
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYA-0093
Application*: IA
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0092
Application*: F, IA, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2565
Application*: E
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2562
Application*: E, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2758
Application*: E, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2034
Application*: WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYY-I1300
Application*: E
Target: IL1R2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1254
Application*: IH, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1146
Application*: IH, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1145
Application*: F, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I0963
Application*: IH, N, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BDI204
Application*: E, R, IF
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9L836
Application*: F
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H4D4F8
Application*: E
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D489
Application*: E, WB, IH, F, IC
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6G5
Application*: E
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 49/20
Application*: E, WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C6
Application*: WB
Target: IL1R2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G12
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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