Mouse Recombinant IL1R2 protein, hFc Tag (V2LY-0526-LY8507)

Name: Mouse Recombinant IL1R2 protein, hFc Tag
SKU: V2LY-0526-LY8507
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

hFc Tag

Protein Construction

This product is Mouse Recombinant IL1R2 protein, hFc Tag consist of Amino Acid: 1-355 and predicts a molecular mass of 65.1 kDa.

Molecule Mass

65.1 kDa

Sequence

Amino Acid: 1-355

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 1 Receptor Type 2

Function

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Biological Process

Immune response Source: ProtInc
Negative regulation of cytokine production involved in inflammatory response Source: Ensembl
Negative regulation of interleukin-1 alpha production Source: Ensembl
Negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Negative regulation of protein processing Source: Ensembl

Cellular Location

Isoform Short: Secreted
Isoform Long: Cell membrane

Topology

Extracellular: 14-343
Helical: 344-369
Cytoplasmic: 370-398

PTM

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.

Li, M., Song, J., Yin, P., Chen, H., Wang, Y., Xu, C., ... & Zhong, D. (2023). Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β–IL1R2 pair in acute inflammatory demyelinating polyneuropathy. Scientific Reports, 13(1), 5862.

Chen, L., Huang, H., Zheng, X., Li, Y., Chen, J., Tan, B., ... & Jiang, J. (2022). IL1R2 increases regulatory T cell population in the tumor microenvironment by enhancing MHC-II expression on cancer-associated fibroblasts. Journal for Immunotherapy of Cancer, 10(9).

Liu, Y., Xing, Z., Yuan, M., Xu, B., Chen, L., Zhang, D., ... & Jiang, J. (2022). IL1R2 promotes tumor progression via JAK2/STAT3 pathway in human clear cell renal cell carcinoma. Pathology-Research and Practice, 238, 154069.

Chen, Q., Li, Z., Wang, M., & Li, G. (2022). Over-expression of IL1R2 in PBMCs of patients with coronary artery disease and its clinical significance. Anatolian Journal of Cardiology, 26(9), 710.

Zhang, L., Qiang, J., Yang, X., Wang, D., Rehman, A. U., He, X., ... & Liu, S. (2020). il1r2 blockade suppresses breast tumorigenesis and progression by impairing usp15‐dependent bmi1 stability. Advanced Science, 7(1), 1901728.

Song, X. L., Zhang, F. F., Wang, W. J., Li, X. N., Dang, Y., Li, Y. X., ... & Qi, X. Y. (2020). LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2. Genes & genomics, 42, 1431-1441.

Autenshlyus, A., Arkhipov, S., Mikhailova, E., Marinkin, I., Arkhipova, V., & Varaksin, N. (2019). The relationship between cytokine production, CSF2RA, and IL1R2 expression in mammary adenocarcinoma, tumor histopathological parameters, and lymph node metastasis. Technology in cancer research & treatment, 18, 1533033819883626.

Ocskó, T., Tóth, D. M., Hoffmann, G., Tubak, V., Glant, T. T., & Rauch, T. A. (2018). Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1861(11), 1040-1047.

Li, G., Cui, S., Du, J., Liu, J., Zhang, P., Fu, Y., ... & Chen, S. (2018). Association of GALC, ZNF184, IL1R2 and ELOVL7 with Parkinson’s disease in southern Chinese. Frontiers in aging neuroscience, 10, 402.

Lian, Z., Lv, F. F., Yu, J., & Wang, J. W. (2018). Retracted: The anti‐inflammatory effect of microRNA‐383‐3p interacting with IL1R2 against homocysteine‐induced endothelial injury in rat coronary arteries.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL1R2 protein, hFc Tag (CAT#: V2LY-0526-LY1276)

Cynomolgus Recombinant IL1R2 protein, hFc Tag (CAT#: V2LY-0526-LY1560)

Human Recombinant IL1R2 protein, ECD, His Tag (CAT#: V2LY-0526-LY4808)

Human Recombinant IL1R2 protein, hFc Tag (CAT#: V2LY-0526-LY4809)

Human Recombinant IL1R2 protein (CAT#: V2LY-0526-LY4810)

Mouse Recombinant IL1R2 protein, His Tag (CAT#: V2LY-0526-LY8508)

Rat Recombinant IL1R2 protein, His Tag (CAT#: V2LY-0526-LY9451)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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