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Mouse Anti-IL1R2 Recombinant Antibody (6D489) (CBMAB-I1562-YY)

This product is Mouse antibody that recognizes IL1R2. The antibody 6D489 can be used for immunoassay techniques such as: ELISA, WB, IHC, FC, ICC
See all IL1R2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6D489
Antibody Isotype
IgG1
Application
ELISA, WB, IHC, FC, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.1% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 1 Receptor Type 2
Introduction
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
Entrez Gene ID
7850
UniProt ID
P27930
Alternative Names
Interleukin 1 Receptor Type 2
Function
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Biological Process
Immune response Source: ProtInc
Negative regulation of cytokine production involved in inflammatory response Source: Ensembl
Negative regulation of interleukin-1 alpha production Source: Ensembl
Negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Negative regulation of protein processing Source: Ensembl
Cellular Location
Isoform Short: Secreted
Isoform Long: Cell membrane
Topology
Extracellular: 14-343
Helical: 344-369
Cytoplasmic: 370-398
PTM
A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.

Li, M., Song, J., Yin, P., Chen, H., Wang, Y., Xu, C., ... & Zhong, D. (2023). Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β–IL1R2 pair in acute inflammatory demyelinating polyneuropathy. Scientific Reports, 13(1), 5862.

Chen, L., Huang, H., Zheng, X., Li, Y., Chen, J., Tan, B., ... & Jiang, J. (2022). IL1R2 increases regulatory T cell population in the tumor microenvironment by enhancing MHC-II expression on cancer-associated fibroblasts. Journal for Immunotherapy of Cancer, 10(9).

Liu, Y., Xing, Z., Yuan, M., Xu, B., Chen, L., Zhang, D., ... & Jiang, J. (2022). IL1R2 promotes tumor progression via JAK2/STAT3 pathway in human clear cell renal cell carcinoma. Pathology-Research and Practice, 238, 154069.

Chen, Q., Li, Z., Wang, M., & Li, G. (2022). Over-expression of IL1R2 in PBMCs of patients with coronary artery disease and its clinical significance. Anatolian Journal of Cardiology, 26(9), 710.

Zhang, L., Qiang, J., Yang, X., Wang, D., Rehman, A. U., He, X., ... & Liu, S. (2020). il1r2 blockade suppresses breast tumorigenesis and progression by impairing usp15‐dependent bmi1 stability. Advanced Science, 7(1), 1901728.

Song, X. L., Zhang, F. F., Wang, W. J., Li, X. N., Dang, Y., Li, Y. X., ... & Qi, X. Y. (2020). LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2. Genes & genomics, 42, 1431-1441.

Autenshlyus, A., Arkhipov, S., Mikhailova, E., Marinkin, I., Arkhipova, V., & Varaksin, N. (2019). The relationship between cytokine production, CSF2RA, and IL1R2 expression in mammary adenocarcinoma, tumor histopathological parameters, and lymph node metastasis. Technology in cancer research & treatment, 18, 1533033819883626.

Ocskó, T., Tóth, D. M., Hoffmann, G., Tubak, V., Glant, T. T., & Rauch, T. A. (2018). Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1861(11), 1040-1047.

Li, G., Cui, S., Du, J., Liu, J., Zhang, P., Fu, Y., ... & Chen, S. (2018). Association of GALC, ZNF184, IL1R2 and ELOVL7 with Parkinson’s disease in southern Chinese. Frontiers in aging neuroscience, 10, 402.

Lian, Z., Lv, F. F., Yu, J., & Wang, J. W. (2018). Retracted: The anti‐inflammatory effect of microRNA‐383‐3p interacting with IL1R2 against homocysteine‐induced endothelial injury in rat coronary arteries.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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