Mouse Anti-IL1R2 Recombinant Antibody (CBT4736) (V2LY-0625-LY1574)

Name: Mouse Anti-IL1R2 Recombinant Antibody (CBT4736)
SKU: V2LY-0625-LY1574
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-IL1R2 Recombinant Antibody (CBT4736) (V2LY-0625-LY1574) in ELISA

Mouse Anti-IL1R2 Recombinant Antibody (CBT4736) (V2LY-0625-LY1574) in WB

Mouse Anti-IL1R2 Recombinant Antibody (CBT4736) (V2LY-0625-LY1574) in FC

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4736

Application

WB, FC

Immunogen

Purified recombinant fragment of human CD121B (AA: extra 14-343) expressed in HEK293-6e cells supernatant.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 1 Receptor Type 2

Entrez Gene ID

7850

UniProt ID

P27930

Function

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Biological Process

Immune response Source: ProtInc
Negative regulation of cytokine production involved in inflammatory response Source: Ensembl
Negative regulation of interleukin-1 alpha production Source: Ensembl
Negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Negative regulation of protein processing Source: Ensembl

Cellular Location

Isoform Short: Secreted
Isoform Long: Cell membrane

Topology

Extracellular: 14-343
Helical: 344-369
Cytoplasmic: 370-398

PTM

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.

Li, M., Song, J., Yin, P., Chen, H., Wang, Y., Xu, C., ... & Zhong, D. (2023). Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β–IL1R2 pair in acute inflammatory demyelinating polyneuropathy. Scientific Reports, 13(1), 5862.

Chen, L., Huang, H., Zheng, X., Li, Y., Chen, J., Tan, B., ... & Jiang, J. (2022). IL1R2 increases regulatory T cell population in the tumor microenvironment by enhancing MHC-II expression on cancer-associated fibroblasts. Journal for Immunotherapy of Cancer, 10(9).

Liu, Y., Xing, Z., Yuan, M., Xu, B., Chen, L., Zhang, D., ... & Jiang, J. (2022). IL1R2 promotes tumor progression via JAK2/STAT3 pathway in human clear cell renal cell carcinoma. Pathology-Research and Practice, 238, 154069.

Chen, Q., Li, Z., Wang, M., & Li, G. (2022). Over-expression of IL1R2 in PBMCs of patients with coronary artery disease and its clinical significance. Anatolian Journal of Cardiology, 26(9), 710.

Zhang, L., Qiang, J., Yang, X., Wang, D., Rehman, A. U., He, X., ... & Liu, S. (2020). il1r2 blockade suppresses breast tumorigenesis and progression by impairing usp15‐dependent bmi1 stability. Advanced Science, 7(1), 1901728.

Song, X. L., Zhang, F. F., Wang, W. J., Li, X. N., Dang, Y., Li, Y. X., ... & Qi, X. Y. (2020). LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2. Genes & genomics, 42, 1431-1441.

Autenshlyus, A., Arkhipov, S., Mikhailova, E., Marinkin, I., Arkhipova, V., & Varaksin, N. (2019). The relationship between cytokine production, CSF2RA, and IL1R2 expression in mammary adenocarcinoma, tumor histopathological parameters, and lymph node metastasis. Technology in cancer research & treatment, 18, 1533033819883626.

Ocskó, T., Tóth, D. M., Hoffmann, G., Tubak, V., Glant, T. T., & Rauch, T. A. (2018). Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1861(11), 1040-1047.

Li, G., Cui, S., Du, J., Liu, J., Zhang, P., Fu, Y., ... & Chen, S. (2018). Association of GALC, ZNF184, IL1R2 and ELOVL7 with Parkinson’s disease in southern Chinese. Frontiers in aging neuroscience, 10, 402.

Lian, Z., Lv, F. F., Yu, J., & Wang, J. W. (2018). Retracted: The anti‐inflammatory effect of microRNA‐383‐3p interacting with IL1R2 against homocysteine‐induced endothelial injury in rat coronary arteries.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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