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IL37

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Full Name

Interleukin 37

Function

Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.

Biological Process

Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Immune response2 PublicationsNAS:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of inflammatory responseManual Assertion Based On ExperimentIGI:ARUK-UCL

Cellular Location

Cytoplasm, cytosol; Nucleus; Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647).
Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730).
The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).

PTM

Proteolytically converted to the mature form by CASP1.

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Anti-IL37 antibodies

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Human Recombinant IL37 protein (V2LY-0526-LY4912)

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Target: IL37

Expressed Host: E. coli

Sequence: Amino Acid: 27-192

Mouse Anti-IL37 Recombinant Antibody (A566) (CBMAB-AP10882LY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: A566

Application*: ELISA, IHC, WB

Mouse Anti-IL37 Recombinant Antibody (A565) (CBMAB-AP3925LY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: A565

Application*: ICC, IHC, IP, WB

Mouse Anti-IL37 Recombinant Antibody (CF239) (CBMAB-FT277LY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF239

Application*: ELISA, WB, IHC

Mouse Anti-IL37 Recombinant Antibody (6A6) (CBMAB-A4374-LY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6A6

Application*: WB, E

Mouse Anti-IL37 Recombinant Antibody (CBYY-I1599) (CBMAB-I2769-YY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1599

Application*: E

Mouse Anti-IL37 Recombinant Antibody (CBYY-I1261) (CBMAB-I2430-YY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I1261

Application*: E, WB, IH

Mouse Anti-IL37 Recombinant Antibody (CBYY-I1150) (CBMAB-I2318-YY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-I1150

Application*: E, P, WB

Mouse Anti-IL37 Recombinant Antibody (CBYY-I0899) (CBMAB-I2067-YY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYY-I0899

Application*: N, WB

Mouse Anti-IL37 Recombinant Antibody (899826) (CBMAB-I1744-YY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 899826

Application*: F, MC, IS

Mouse Anti-IL37 Recombinant Antibody (CBYY-I0213) (CBMAB-I0564-YY)

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Target: IL37

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-I0213

Application*: BL

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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