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Mouse Anti-IL37 Recombinant Antibody (6A6) (CBMAB-A4374-LY)

The product is antibody recognizes IL1F7. The antibody 6A6 immunoassay techniques such as: WB, ELISA.
See all IL37 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6A6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
IL1F7 (AAH20637, 1 a.a. ~ 218 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 37
Introduction
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Entrez Gene ID
27178
UniProt ID
Q9NZH6
Alternative Names
FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H4; IL-1RP1; IL1H4; IL1RP1
Function
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Biological Process
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Immune response2 PublicationsNAS:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of inflammatory responseManual Assertion Based On ExperimentIGI:ARUK-UCL
Cellular Location
Cytoplasm, cytosol; Nucleus; Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647).
Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730).
The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).
PTM
Proteolytically converted to the mature form by CASP1.

Schröder, A., Lunding, L. P., Zissler, U. M., Vock, C., Webering, S., Ehlers, J. C., ... & Wegmann, M. (2022). IL‐37 regulates allergic inflammation by counterbalancing pro‐inflammatory IL‐1 and IL‐33. Allergy, 77(3), 856-869.

Rai, V., Dilisio, M. F., Samadi, F., & Agrawal, D. K. (2022). Counteractive Effects of IL-33 and IL-37 on Inflammation in Osteoarthritis. International Journal of Environmental Research and Public Health, 19(9), 5690.

Law, C. C., Puranik, R., Fan, J., Fei, J., Hambly, B. D., & Bao, S. (2021). Clinical implications of IL-32, IL-34 and IL-37 in atherosclerosis: speculative role in cardiovascular manifestations of COVID-19. Frontiers in Cardiovascular Medicine, 8, 630767.

Su, Z., & Tao, X. (2021). Current understanding of IL-37 in human health and disease. Frontiers in immunology, 12, 696605.

Sánchez-Fernández, A., Zandee, S., Amo-Aparicio, J., Charabati, M., Prat, A., Garlanda, C., ... & López-Vales, R. (2021). IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8. Theranostics, 11(1), 1.

Zhao, T., Jin, F., Xiao, D., Wang, H., Huang, C., Wang, X., ... & Hao, J. (2020). IL-37/STAT3/HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer. Theranostics, 10(9), 4088.

Wawrocki, S., Seweryn, M., Kielnierowski, G., Rudnicka, W., Wlodarczyk, M., & Druszczynska, M. (2019). IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB. Plos one, 14(12), e0225556.

Jing, L., Kim, S., Sun, L., Wang, L., Mildner, E., Divaris, K., ... & Offenbacher, S. (2019). IL-37-and IL-35/IL-37-producing plasma cells in chronic periodontitis. Journal of Dental Research, 98(7), 813-821.

Sehat, M., Talaei, R., Dadgostar, E., Nikoueinejad, H., & Akbari, H. (2018). Evaluating serum levels of IL-33, IL-36, IL-37 and gene expression of IL-37 in patients with psoriasis vulgaris. Iranian Journal of Allergy, Asthma and Immunology, 179-187.

Cavalli, G., & Dinarello, C. A. (2018). Suppression of inflammation and acquired immunity by IL‐37. Immunological reviews, 281(1), 179-190.

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For research use only. Not intended for any clinical use.

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