Human IL37 ELISA Kit (V2LY-0626-LY2189)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0046 ng/mL
Detection Range
0.007-0.4 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
24.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Interleukin 37
Function
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Biological Process
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Immune response2 PublicationsNAS:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of inflammatory responseManual Assertion Based On ExperimentIGI:ARUK-UCL
Cellular Location
Cytoplasm, cytosol; Nucleus; Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647).
Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730).
The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).
PTM
Proteolytically converted to the mature form by CASP1.

Schröder, A., Lunding, L. P., Zissler, U. M., Vock, C., Webering, S., Ehlers, J. C., ... & Wegmann, M. (2022). IL‐37 regulates allergic inflammation by counterbalancing pro‐inflammatory IL‐1 and IL‐33. Allergy, 77(3), 856-869.

Rai, V., Dilisio, M. F., Samadi, F., & Agrawal, D. K. (2022). Counteractive Effects of IL-33 and IL-37 on Inflammation in Osteoarthritis. International Journal of Environmental Research and Public Health, 19(9), 5690.

Law, C. C., Puranik, R., Fan, J., Fei, J., Hambly, B. D., & Bao, S. (2021). Clinical implications of IL-32, IL-34 and IL-37 in atherosclerosis: speculative role in cardiovascular manifestations of COVID-19. Frontiers in Cardiovascular Medicine, 8, 630767.

Su, Z., & Tao, X. (2021). Current understanding of IL-37 in human health and disease. Frontiers in immunology, 12, 696605.

Sánchez-Fernández, A., Zandee, S., Amo-Aparicio, J., Charabati, M., Prat, A., Garlanda, C., ... & López-Vales, R. (2021). IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8. Theranostics, 11(1), 1.

Zhao, T., Jin, F., Xiao, D., Wang, H., Huang, C., Wang, X., ... & Hao, J. (2020). IL-37/STAT3/HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer. Theranostics, 10(9), 4088.

Wawrocki, S., Seweryn, M., Kielnierowski, G., Rudnicka, W., Wlodarczyk, M., & Druszczynska, M. (2019). IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB. Plos one, 14(12), e0225556.

Jing, L., Kim, S., Sun, L., Wang, L., Mildner, E., Divaris, K., ... & Offenbacher, S. (2019). IL-37-and IL-35/IL-37-producing plasma cells in chronic periodontitis. Journal of Dental Research, 98(7), 813-821.

Sehat, M., Talaei, R., Dadgostar, E., Nikoueinejad, H., & Akbari, H. (2018). Evaluating serum levels of IL-33, IL-36, IL-37 and gene expression of IL-37 in patients with psoriasis vulgaris. Iranian Journal of Allergy, Asthma and Immunology, 179-187.

Cavalli, G., & Dinarello, C. A. (2018). Suppression of inflammation and acquired immunity by IL‐37. Immunological reviews, 281(1), 179-190.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL37 protein (CAT#: V2LY-0526-LY4912)

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Isotype control

For research use only. Not intended for any clinical use.

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