IL9R

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Interleukin 9 Receptor

This is a receptor for interleukin-9.

Regulation of cell population proliferationManual Assertion Based On ExperimentTAS:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cell membrane; Secreted

Extracellular: 41-270
Helical: 271-291
Cytoplasmic: 292-521